

A Mail Setup wizard opens in which you have to click on Show Profiles options.From the displayed items, click on Mail (Microsoft Outlook 2016).Otherwise, you need to implement the following guidelines : If you are capable enough to resolve misconfiguration in the respective email client then, you can do that first. One of ‘ Outlook Could Not Start last time in safe mode ’ error causes can be the corruption in Microsoft Outlook profile or misconfiguration in settings of the profile. Workaround #2 – Create a New MS Outlook Profile

Restart the Microsoft Outlook application and check whether your problem is resolved or not.At last, click on OK button to update all the changes A wizard appears where you have to uncheck all the checkboxes of those add-ins, which are unwanted.To continue, click on Go in Manage Add-ins Now it is the time view and manages them by eliminating the one, which is of no use. A list of all add-ins that are installed in your Outlook program appears.An ‘Outlook Options’ window gets opened in which you have to click on Add-ins.From the top listed tabs, click on the File tab and select Options.Open Microsoft Outlook 2016 or any other version on your Windows PC.Now disable unnecessary add-ins from Outlook email app, with help of following steps : If Microsoft Outlook gets started in safe mode, it means that ‘ Outlook failed to launch in safe mode ‘ error is occurring because of one of the available add-in. Finally, you will be able to work with Microsoft Outlook by opening it in the safe mode.If password protection is enabled in the chosen profile, enter the password in the current dialog box.An Outlook opening dialog box appears in which you have to select the profile, which was showing ‘ Outlook could not start last time in Safe Mode ’ error.Click on OK button to execute the command.

